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New weight-loss compound melts fat without curbing appetite — and preserves muscle

Wednesday, September 2, 2026


University of California, Berkeley scientists tested a compound called TOFA on obese mice and found it increased energy expenditure without reducing lean muscle mass, according to research the institution reported. Semaglutide, a widely used weight-loss medication, has been associated with lean muscle loss in some studies. The researchers did not specify a timeline for testing the compound in humans or its availability for clinical use.

Original reporting: https://www.foxnews.com/health/new-weight-loss-compound-melts-fat-without-curbing-appetite-preserves-muscle

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